||Marisa S. Bartolomei, PhD
Perelman Professor of Cell and Developmental Biology
Professor of Genetics, University of Pennsylvania School of Medicine
Director of IRM Program in Reproductive Medicine, University of Pennsylvania
Co-Director Epigenetics Program, University of Pennsylvania Perelman School of Medicine
Marisa S. Bartolomei received her BS in Biochemistry at the University of Maryland in 1982. She then obtained her PhD in 1987 in the Biochemistry, Cell & Molecular Biology program at the Johns Hopkins University School of Medicine. She trained as a postdoctoral fellow with Dr. Shirley Tilghman at Princeton University. In 1993, Dr. Bartolomei was appointed as an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine and was promoted to Associate Professor with tenure in 1999 and Professor in 2006. She was also an investigator of the Howard Hughes Medical Institute for 10 years. In 2006, Dr. Bartolomei received the Society for Women's Health Research Medtronics Prize for Contributions to Women's Health.
Dr. Bartolomei participates extensively graduate and medical education. Among her teaching activities, she the associate director of an NIH-funded training grant program. She has served on numerous NIH sponsored grant review panels and is a member the Human Molecular Genetics and Molecular and Cellular Biology editorial boards and the Science Board of Reviewing Editors. In 2006 Dr. Bartolomei organized Gordon Research Conference on Mammalian Gametogenesis and Embryogenesis and she is co-chair of the 2011 Gordon Research Conference on Epigenetics.
Dr. Bartolomei’s research addresses the epigenetic mechanisms of genomic imprinting and X inactivation. Her lab is studying the processes by which parental alleles are distinguished in mammals and the mechanisms that lead to loss of imprinting in individuals with Beckwith-Wiedemann Syndrome and Silver Russell Syndrome. She is also addressing the epigenetic consequences of various environmental perturbations to gametes and early embryos. Finally, she involved in a collaboration that aims to reactivate MeCP2 from the inactive X chromosome in Rett’s Syndrome patients.
Martin M. Matzuk, MD, PhD
Director, Center for Drug Discovery
Stuart A. Wallace Chair and Professor, Department of Pathology & Immunology
Robert L. Moody, Sr. Chair, Department of Pathology & Immunology
Baylor College of Medicine
Director, Clinical Chemistry, Ben Taub Hospital
Martin M. Matzuk, M.D., Ph.D., is the Stuart A. Wallace Chair and Professor of Pathology and Immunology at Baylor College of Medicine and Director of Clinical Chemistry at Ben Taub General Hospital. He graduated from the University of Chicago with a B.A. with Honors in Biology, received his M.D. and Ph.D. from Washington University School of Medicine, and performed his residency training at the University of Pennsylvania and Baylor College of Medicine. He is a board-certified clinical pathologist, cancer biologist and reproductive biologist.
Dr. Matzuk has over 25 years of research experience deciphering germ cell, hormonal, and TGF beta superfamily signaling pathways in cancer and fertility. He has published more than 270 papers, holds 12 patents for his biomedical research discoveries, and has lectured at more than 140 symposia in 27 countries. He has received many prestigious honors including the Roy Greep Award from the Endocrine Society, the HypoCCS Award from Eli Lilly, the Pfizer Outstanding Investigator Award from the American Society for Investigative Pathology, the Society for the Study of Reproduction Research Award, and a National Institutes of Health MERIT award.
Dr. Matzuk has held several key national positions of authority. He was chair of the National Institutes of Health Cellular, Molecular and Integrative Reproduction study section (2004-2006) and was co-chair of the Burroughs Wellcome Fund advisory committee for the Career Awards in the Biomedical Sciences (2004-2006) and subsequently the Career Awards in the Medical Sciences (2006-2007). He was a member of the Institute of Medicine/National Academy of Sciences Committee on New Frontiers in Contraceptive Research (2003-2004). He is currently a member of the Board of Reviewing Editors for Science and Treasurer of the Society for the Study of Reproduction.
Yoel Sadovsky, MD
Executive Director, Magee-Womens Research Institute
Elsie Hilliard Hillman Chair of Women’s Health Research
Distinguised Professor of OBGYN, Microbiology and Molecular Genetics
Vice Chair (research), Department of OBGYN and Reproductive Sciences
Associate Dean, Women's Health Research and Reproductive Sciences
University of Pittsburgh
Yoel Sadovsky received his MD degree from the Hebrew University-Hadassah Medical School in Jerusalem in 1986, followed by OBGYN residency at Washington University in St. Louis and maternal-fetal medicine and postdoctoral research fellowships at the University of California, San Francisco. He then returned to Washington University as a reproductive biologist and specialist in high-risk pregnancy, where he was appointed tenured professor of OBGYN, and Cell Biology and Physiology in 2004. Dr. Sadovsky served as director of the Maternal-Fetal Medicine Fellowship at Washington University between 1997-07, and as Director, Division of Maternal-Fetal Medicine and Ultrasound from 1999-2007. In 2007, he assumed Scientific Directorship of Magee-Womens Research Institute (MWRI) in the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of Pittsburgh. The Institute is home to 60 faculty members and another 40 affiliate members within the greater University of Pittsburgh community, all engaged in basic, translational and clinical research in the fields of reproductive biology, development, and women’s health.
Dr. Sadovsky’s research on feto-placental development and trophoblast function parallels his clinical expertise in maternal-fetal medicine. Using human placental cells as well as mouse models, he studies molecular pathways, including miRNAs, that govern placental adaptive response to stress, and the effect of cell injury on placental lipid trafficking. His NIH funded investigation has resulted in the publication of numerous scientific articles and his selection for the Society for Gynecologic Investigation’s (SGI) President’s Achievement Award in 2004. He has served on several National Institute of Child Health and Human Development (NICHD) study sections, chaired the NICHD Maternal-Fetal Biology Research Study Section in 2005-06, the NICHD Genomic and Proteomic Network for Preterm Birth Research steering committee, and is currently a member of the NICHD Advisory Council. He chairs the March of Dimes Prematurity Research Initiative Advisory Committee, and is a member of the SGI Council and the Society for Maternal-Fetal Medicine (SMFM) Scholarly Activities Committee. Dr. Sadovsky has trained numerous students, residents and post-doctoral fellows, whose work has been recognized and funded by the SGI, SMFM and the American College of Obstetricians and Gynecologists (ACOG). He is the Research Director of the Magee-Womens Basic and Translational Reproductive Health Training Program, an NIH-funded program to prepare junior faculty for a productive investigative career in reproductive biology and medicine.