Khursheed Iqbal, PhD
Research Assistant Professor
Pathology and Laboratory Medicine
Ph.D., Hannover Medical School (MHH), Germany, 2008
Postdoctoral, City of Hope Medical Center, 2009-2012
Postdoctoral, UC Davis, 2012-2013
Postdoctoral, University of Nevada, 2013-2014
Postdoctoral, University of Kansas Medical Center, 2014-2016
Effects of endocrine disrupting chemicals (EDCs) on reproduction and pregnancy.
EDCs are environmental chemicals that interfere with critical cell signaling pathways and causes harmful developmental, reproductive, neurological, and immune effects. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that modulates gene expression facilitating adaptations to environmental changes. We investigate the impact of EDCs acting through AHR on establishment of the hemochorial placenta. Our research approach utilizes trophoblast stem cells and mutant rat models, including the development of a humanized AHR rat model possessing polymorphisms affecting AHR action, and translational experiments with human placental tissues. The actions of EDCs on placental development have profound health relevance because the placenta plays an essential role in regulating maternal health, fetal growth and maturation, and is also critical for long-term postnatal health.
Iqbal K, Tran DA, Li AX, Warden C, Bai AY, Singh P, Wu X, Pfeifer GP, Szabó PE. Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming. Genome Biol. 2015 Mar 27;16:59.
Iqbal K, Chitwood JL, Meyers-Brown GA, Roser JF, Ross PJ. RNA-seq transcriptome profiling of equine inner cell mass and trophectoderm. Biol Reprod. 2014 Mar;90(3):61.
Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi L, He X, Jin SG, Iqbal K, Shi YG, Deng Z, Szabó PE, Pfeifer GP, Li J, Xu GL. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011 Sep 4;477(7366):606-10.
Kang ER*, Iqbal K*, Tran DA, Rivas GE, Singh P, Pfeifer GP, Szabó PE. Effects of endocrine disruptors on imprinted gene expression in the mouse embryo. Epigenetics. 2011 Jul;6(7):937-50.
Iqbal K, Jin SG, Pfeifer GP, Szabó PE. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3642-7.
Iqbal K, Kues WA, Baulain U, Garrels W, Herrmann D, Niemann H. Species-specific telomere length differences between blastocyst cell compartments and ectopic telomere extension in early bovine embryos by human telomerase reverse transcriptase. Biol Reprod. 2011 Apr;84(4):723-33.